Reaction Details
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Report a problem with these dataTarget
cAMP-dependent protein kinase catalytic subunit beta
Ligand
BDBM15211
Substrate
n/a
Ki
50±n/a nM
Comments
PDSP_6135
Citation
Braverman, AS; Tibb, AS; Ruggieri, MR M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. I. Normal rat bladder. J Pharmacol Exp Ther 316:869-74 (2006) [PubMed] Article More Info.:
Target
Name:
cAMP-dependent protein kinase catalytic subunit beta
Synonyms:
KAPCB_RAT | PKA | Pkacb | Prkacb | cAMP-dependent protein kinase catalytic subunit beta
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40715.41
Organism:
RAT
Description:
PKA 0 RAT::P68182
Residue:
351
Sequence:
MGNTAIAKKGSEVESVKEFLAKAKEDFLRKWENPPPSNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEEIRVSITEKCGKEFCEF
Inhibitor
Name:
BDBM15211
Synonyms:
CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[(2E)-3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide | N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C20H20BrN3O2S
Mol. Mass.:
446.361
SMILES:
Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1
Structure:
