Target
Ret proto-oncogene
Ligand
BDBM50237710
Substrate
n/a
Ki
8678±n/a nM
Comments
PDSP_6404
Citation
 Melnick, JSJanes, JKim, SChang, JYSipes, DGGunderson, DJarnes, LMatzen, JTGarcia, MEHood, TLBeigi, RXia, GHarig, RAAsatryan, HYan, SFZhou, YGu, XJSaadat, AZhou, VKing, FJShaw, CMSu, AIDowns, RGray, NSSchultz, PGWarmuth, MCaldwell, JS An efficient rapid system for profiling the cellular activities of molecular libraries. Proc Natl Acad Sci U S A 103:3153-8 (2006) [PubMed]  Article 
Target
Name:
Ret proto-oncogene
Synonyms:
RET proto-oncogene tyrosine kinase receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
3923.37
Organism:
Homo sapiens (Human)
Description:
Ret proto-oncogene 0 HUMAN::Q9UE13
Residue:
35
Sequence:
NASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQD
  
Inhibitor
Name:
BDBM50237710
Synonyms:
4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide | AMN 107 | AMN107 | CHEMBL255863 | NILOTINIB | US11649218, Example Nilotinib
Type:
Small organic molecule
Emp. Form.:
C28H22F3N7O
Mol. Mass.:
529.5158
SMILES:
Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Structure:
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