Reaction Details Report a problem with these data
Target
Delta-type opioid receptor
Ligand
BDBM86967
Substrate
n/a
Ki
160±n/a nM
Comments
PDSP_8588
Citation
 Le Bourdonnec, B; Barker, WM; Belanger, S; Wiant, DD; Conway-James, NC; Cassel, JA; O'Neill, TJ; Little, PJ; DeHaven, RN; DeHaven-Hudkins, DL; Dolle, RE Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett 18:2006-12 (2008) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM86967
Synonyms:
(S)-3-biphenyl-4-yl-2-{3-[(3R,4R)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-propionylamino}-propionic acid | CAS_44453925 | NSC_44453925
Type:
Small organic molecule
Emp. Form.:
C31H36N2O4
Mol. Mass.:
500.6285
SMILES:
CC1CN(CCC(=O)NC(Cc2ccc(cc2)-c2ccccc2)C(O)=O)CCC1(C)c1cccc(O)c1
Structure:
Search PDB for entries with ligand similarity: