Reaction Details
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GTP-binding nuclear protein GSP1/CNR1
Ligand
BDBM50080103
Substrate
n/a
Ki
70.3±n/a nM
Comments
PDSP_8599
Citation
Wang, H; Duffy, RA; Boykow, GC; Chackalamannil, S; Madison, VS Identification of novel cannabinoid CB1 receptor antagonists by using virtual screening with a pharmacophore model. J Med Chem 51:2439-46 (2008) [PubMed] Article More Info.:
Target
Name:
GTP-binding nuclear protein GSP1/CNR1
Synonyms:
CANNABINOID CB1 | CNR1 | CST17 | GSP1 | GSP1_YEAST | GTP-binding nuclear protein GSP1/CNR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24810.06
Organism:
Saccharomyces cerevisiae
Description:
CANNABINOID CB1 CNR1 0::P32835
Residue:
219
Sequence:
MSAPAANGEVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATIGVEVHPLSFYTNFGEIKFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLAGNPQLEFVASPALAPPEVQVDEQLMQQYQQEMEQATALPLPDEDDADL
Inhibitor
Name:
BDBM50080103
Synonyms:
5,5-Bis-(4-bromo-phenyl)-3-(2-morpholin-4-yl-ethyl)-imidazolidine-2,4-dione | 5,5-bis(4-bromophenyl)-3-(2-morpholinoethyl)imidazolidine-2,4-dione | CHEMBL50925
Type:
Small organic molecule
Emp. Form.:
C21H21Br2N3O3
Mol. Mass.:
523.218
SMILES:
Brc1ccc(cc1)C1(NC(=O)N(CCN2CCOCC2)C1=O)c1ccc(Br)cc1
Structure:
