Reaction Details Report a problem with these data
Target
GTP-binding nuclear protein GSP1/CNR1
Ligand
BDBM21278
Substrate
n/a
Ki
1.98±n/a nM
Comments
PDSP_7040
Citation
 Wang, H; Duffy, RA; Boykow, GC; Chackalamannil, S; Madison, VS Identification of novel cannabinoid CB1 receptor antagonists by using virtual screening with a pharmacophore model. J Med Chem 51:2439-46 (2008) [PubMed]  Article 
Target
Name:
GTP-binding nuclear protein GSP1/CNR1
Synonyms:
CANNABINOID CB1 | CNR1 | CST17 | GSP1 | GSP1_YEAST | GTP-binding nuclear protein GSP1/CNR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24810.06
Organism:
Saccharomyces cerevisiae
Description:
CANNABINOID CB1 CNR1 0::P32835
Residue:
219
Sequence:
MSAPAANGEVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATIGVEVHPLSFYTNFGEIKFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLAGNPQLEFVASPALAPPEVQVDEQLMQQYQQEMEQATALPLPDEDDADL
  
Inhibitor
Name:
BDBM21278
Synonyms:
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide | Acomplia | CHEMBL111 | CHEMBL558598 | RIMONABANT HYDROCHLORIDE | Rimonabant | SR 141716A | SR141716 | SR141716A | [3H]Rimonabant | [3H]SR141716A
Type:
Small organic molecule
Emp. Form.:
C22H21Cl3N4O
Mol. Mass.:
463.787
SMILES:
Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1
Structure:
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