Reaction Details
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GTP-binding nuclear protein GSP2/CNR2
Ligand
BDBM50176988
Substrate
n/a
Ki
21±n/a nM
Comments
PDSP_8602
Citation
Wang, H; Duffy, RA; Boykow, GC; Chackalamannil, S; Madison, VS Identification of novel cannabinoid CB1 receptor antagonists by using virtual screening with a pharmacophore model. J Med Chem 51:2439-46 (2008) [PubMed] Article More Info.:
Target
Name:
GTP-binding nuclear protein GSP2/CNR2
Synonyms:
CANNABINOID CB2 | CNR2 | GSP2 | GSP2_YEAST | GTP-binding nuclear protein GSP2/CNR2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24990.72
Organism:
Saccharomyces cerevisiae
Description:
CANNABINOID CB2 CNR2 0::P32836
Residue:
220
Sequence:
MSAPAQNNAEVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATIGVEVHPLSFYTNFGEIKFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLAGNPQLEFVASPALAPPEVQVDEQLMHQYQQEMDQATALPLPDEDDADL
Inhibitor
Name:
BDBM50176988
Synonyms:
8-Chloro-1-(2,4-dichloro-phenyl)-1,3a,4,5,6,10b-hexahydro-1,2-diaza-benzo[e]azulene-3-carboxylic acid piperidin-1-ylamide | 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide | 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide | 8-chloro-1-(2,4-dichloro-phenyl)-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulene-3-carboxylic acid piperidin-1-ylamide | CHEMBL376700
Type:
Small organic molecule
Emp. Form.:
C24H23Cl3N4O
Mol. Mass.:
489.825
SMILES:
Clc1ccc(c(Cl)c1)-n1nc(C(=O)NN2CCCCC2)c2CCCc3cc(Cl)ccc3-c12
Structure:
