Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM87256
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
7964±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM87256
Synonyms:
MLS000040549 | N-cyclohexyl-N-[(2-keto-1H-quinolin-3-yl)methyl]isonicotinamide | N-cyclohexyl-N-[(2-oxidanylidene-1H-quinolin-3-yl)methyl]pyridine-4-carboxamide | N-cyclohexyl-N-[(2-oxo-1H-quinolin-3-yl)methyl]-4-pyridinecarboxamide | N-cyclohexyl-N-[(2-oxo-1H-quinolin-3-yl)methyl]pyridine-4-carboxamide | SMR000044678 | cid_663857
Type:
Small organic molecule
Emp. Form.:
C22H23N3O2
Mol. Mass.:
361.4369
SMILES:
O=C(N(Cc1cc2ccccc2[nH]c1=O)C1CCCCC1)c1ccncc1
Structure:
Search PDB for entries with ligand similarity: