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Target
Polyadenylate-binding protein 1
Ligand
BDBM87612
Substrate
n/a
Meas. Tech.
Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay
IC50
49100±n/a nM
Citation
 PubChem, PC Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM87612
Synonyms:
3-Chloro-4-(4-methyl-piperazin-1-yl)-1-phenethyl-pyrrole-2,5-dione | 3-chloranyl-4-(4-methylpiperazin-1-yl)-1-(2-phenylethyl)pyrrole-2,5-dione | 3-chloro-4-(4-methyl-1-piperazinyl)-1-(2-phenylethyl)pyrrole-2,5-dione | 3-chloro-4-(4-methylpiperazin-1-yl)-1-(2-phenylethyl)pyrrole-2,5-dione | 3-chloro-4-(4-methylpiperazino)-1-phenethyl-3-pyrroline-2,5-quinone | MLS000075936 | SMR000014936 | cid_653866
Type:
Small organic molecule
Emp. Form.:
C17H20ClN3O2
Mol. Mass.:
333.813
SMILES:
CN1CCN(CC1)C1=C(Cl)C(=O)N(CCc2ccccc2)C1=O |c:8|
Structure:
Search PDB for entries with ligand similarity: