Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM87630
Substrate
n/a
Meas. Tech.
Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay
IC50
55420±n/a nM
Citation
 PubChem, PC Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM87630
Synonyms:
1-(2-methoxyethyl)-3-(phenylsulfonyl)-2H-imidazo[4,5-b]quinoxaline | 3-(benzenesulfonyl)-1-(2-methoxyethyl)-2H-imidazo[4,5-b]quinoxaline | 3-besyl-1-(2-methoxyethyl)-2H-imidazo[4,5-b]quinoxaline | MLS000041355 | SMR000045837 | cid_664837
Type:
Small organic molecule
Emp. Form.:
C18H18N4O3S
Mol. Mass.:
370.426
SMILES:
COCCN1CN(c2nc3ccccc3nc12)S(=O)(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: