Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM34377
Substrate
n/a
Meas. Tech.
Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay
IC50
55550±n/a nM
Citation
 PubChem, PC Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM34377
Synonyms:
3-keto-2-pyrrolidino-4H-1,4-benzothiazine-6-carboxylic acid | 3-oxidanylidene-2-pyrrolidin-1-yl-4H-1,4-benzothiazine-6-carboxylic acid | 3-oxo-2-(1-pyrrolidinyl)-4H-1,4-benzothiazine-6-carboxylic acid | 3-oxo-2-pyrrolidin-1-yl-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid | 3-oxo-2-pyrrolidin-1-yl-4H-1,4-benzothiazine-6-carboxylic acid | MLS000045953 | SMR000031562 | cid_3240735
Type:
Small organic molecule
Emp. Form.:
C13H14N2O3S
Mol. Mass.:
278.327
SMILES:
OC(=O)c1ccc2SC(N3CCCC3)C(=O)Nc2c1
Structure:
Search PDB for entries with ligand similarity: