Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM87668
Substrate
n/a
Meas. Tech.
Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay
IC50
32000±n/a nM
Citation
 PubChem, PC Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM87668
Synonyms:
6-amino-5-cyano-2-(2-ethoxy-2-keto-ethyl)-4-(5-methyl-2-furyl)-4H-pyran-3-carboxylic acid ethyl ester | 6-amino-5-cyano-2-(2-ethoxy-2-oxoethyl)-4-(5-methyl-2-furanyl)-4H-pyran-3-carboxylic acid ethyl ester | MLS000043612 | SMR000020628 | cid_3241774 | ethyl 6-amino-5-cyano-2-(2-ethoxy-2-oxoethyl)-4-(5-methyl-2-furyl)-4H-pyran-3-carboxylate | ethyl 6-amino-5-cyano-2-(2-ethoxy-2-oxoethyl)-4-(5-methylfuran-2-yl)-4H-pyran-3-carboxylate | ethyl 6-azanyl-5-cyano-2-(2-ethoxy-2-oxidanylidene-ethyl)-4-(5-methylfuran-2-yl)-4H-pyran-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H20N2O6
Mol. Mass.:
360.3612
SMILES:
CCOC(=O)CC1=C(C(C(C#N)C(=N)O1)c1ccc(C)o1)C(=O)OCC |t:6|
Structure:
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