Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM87623
Substrate
n/a
Meas. Tech.
Dose-response secondary confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay using Cy5 labeled peptide
IC50
>66000±n/a nM
Citation
 PubChem, PC Dose-response secondary confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay using Cy5 labeled peptide PubChem Bioassay (2012)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM87623
Synonyms:
3-(5-cycloheptylidene-4-keto-2-thioxo-thiazolidin-3-yl)propionic acid | 3-(5-cycloheptylidene-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl)propanoic acid | 3-(5-cycloheptylidene-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)propanoic acid | 3-(5-cycloheptylidene-4-oxo-2-sulfanylidene-3-thiazolidinyl)propanoic acid | MLS000039094 | SMR000037169 | cid_659433
Type:
Small organic molecule
Emp. Form.:
C13H17NO3S2
Mol. Mass.:
299.409
SMILES:
[#8]-[#6](=O)-[#6]-[#6]-[#7]-1-[#6](=S)-[#16]\[#6](-[#6]-1=O)=[#6]-1\[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-1
Structure:
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