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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM88892
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
658±96 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM88892
Synonyms:
MLS000401485 | N-(2-chlorophenyl)-2-[(2E)-2-[(2-morpholin-4-yl-4-phenyl-1,3-thiazol-5-yl)methylidene]hydrazinyl]-5-nitro-benzenesulfonamide | N-(2-chlorophenyl)-2-[(2E)-2-[(2-morpholin-4-yl-4-phenyl-1,3-thiazol-5-yl)methylidene]hydrazinyl]-5-nitrobenzenesulfonamide | N-(2-chlorophenyl)-2-[(2E)-2-[[2-(4-morpholinyl)-4-phenyl-5-thiazolyl]methylidene]hydrazinyl]-5-nitrobenzenesulfonamide | N-(2-chlorophenyl)-2-[(N'E)-N'-[(2-morpholino-4-phenyl-thiazol-5-yl)methylene]hydrazino]-5-nitro-benzenesulfonamide | SMR000243227 | cid_5993604
Type:
Small organic molecule
Emp. Form.:
C26H23ClN6O5S2
Mol. Mass.:
599.081
SMILES:
[O-][N+](=O)c1ccc(\[NH+]=N\[CH-]c2sc(nc2-c2ccccc2)N2CCOCC2)c(c1)S(=O)(=O)Nc1ccccc1Cl
Structure:
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