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Target
Dual specificity protein phosphatase 3
Ligand
BDBM81080
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
740±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM81080
Synonyms:
4-[(4-ethyl-1-piperazinyl)-mercaptomethylidene]-1-cyclohexa-2,5-dienone | 4-[(4-ethyl-1-piperazinyl)carbonothioyl]phenol | 4-[(4-ethylpiperazin-1-yl)-sulfanyl-methylidene]cyclohexa-2,5-dien-1-one | 4-[(4-ethylpiperazin-1-yl)-sulfanylmethylidene]cyclohexa-2,5-dien-1-one | 4-[(4-ethylpiperazino)-mercapto-methylene]cyclohexa-2,5-dien-1-one | MLS000621546 | SMR000299713 | US11225469, Compound 15 | cid_5424195
Type:
Small organic molecule
Emp. Form.:
C13H18N2OS
Mol. Mass.:
250.36
SMILES:
CCN1CCN(CC1)C(=S)c1ccc(O)cc1
Structure:
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