Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM89068
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
570±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM89068
Synonyms:
4-chlorobenzoic acid [(Z)-[amino-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylidene]amino] ester | 4-chlorobenzoic acid [(Z)-[amino-[4-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]amino] ester | MLS-0454737.0001 | [(Z)-[amino-[4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]amino] 4-chlorobenzoate | [(Z)-[azanyl-[4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]amino] 4-chloranylbenzoate | cid_9580892
Type:
Small organic molecule
Emp. Form.:
C20H13ClF3N3O3
Mol. Mass.:
435.784
SMILES:
NC(=NOC(=O)c1ccc(Cl)cc1)c1ccc(Oc2ccc(cn2)C(F)(F)F)cc1 |w:2.2|
Structure:
Search PDB for entries with ligand similarity: