Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77695
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
34300±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77695
Synonyms:
7-(2-furanylmethyl)-3-(2-methylpropyl)-5,6-diphenyl-4-pyrrolo[2,3-d]pyrimidinimine | 7-(2-furylmethyl)-3-isobutyl-5,6-diphenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-imine | 7-(furan-2-ylmethyl)-3-(2-methylpropyl)-5,6-diphenyl-pyrrolo[2,3-d]pyrimidin-4-imine | 7-(furan-2-ylmethyl)-3-(2-methylpropyl)-5,6-diphenylpyrrolo[2,3-d]pyrimidin-4-imine | MLS000535025 | SMR000142461 | [7-(2-furfuryl)-3-isobutyl-5,6-diphenyl-pyrrolo[2,3-d]pyrimidin-4-ylidene]amine | cid_1312356
Type:
Small organic molecule
Emp. Form.:
C27H26N4O
Mol. Mass.:
422.5215
SMILES:
CC(C)Cn1cnc2n(Cc3ccco3)c(c(-c3ccccc3)c2c1=N)-c1ccccc1
Structure:
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