Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77858
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
15800±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77858
Synonyms:
1-Ethyl-2-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-1H-benzoimidazole | 1-ethyl-2-[4-(4-methoxyphenyl)sulfonyl-1-piperazinyl]benzimidazole | 1-ethyl-2-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]benzimidazole | 1-ethyl-2-[4-(4-methoxyphenyl)sulfonylpiperazino]benzimidazole | MLS001212858 | SMR000503833 | cid_1462216
Type:
Small organic molecule
Emp. Form.:
C20H24N4O3S
Mol. Mass.:
400.495
SMILES:
CCn1c(nc2ccccc12)N1CCN(CC1)S(=O)(=O)c1ccc(OC)cc1
Structure:
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