Reaction Details Report a problem with these data
Target
Zinc finger protein GLI1
Ligand
BDBM89350
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay
IC50
647±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Zinc finger protein GLI1
Synonyms:
GLI1_MOUSE | Gli | Gli1 | Glioma-associated oncogene homolog
Type:
PROTEIN
Mol. Mass.:
118579.34
Organism:
Mus musculus
Description:
EBI_101259
Residue:
1111
Sequence:
MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGAARETSSCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHPQSRGPRATCQLKSELDMMVGKCPEDPLEGDMSSPNSTGTQDHLLGMLDGREDLEREEKPEPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKREREGGSGREESRLTVPESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDLSSLDEGPCVSATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVSLDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGASSLPGLTPAQHYMLRARYASARGSGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFKSLGCVHTPPSVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLNPYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPENWGEFPSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLVCNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPASANHKSGSYPAPSPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPEVGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTPSPSGPPNMAVGNMSVLLGSLPGETQFLNSSA
  
Inhibitor
Name:
BDBM89350
Synonyms:
7-(2,4-dichlorobenzyl)-8-(2-furfurylamino)-1,3-dimethyl-xanthine | 7-[(2,4-dichlorophenyl)methyl]-8-(2-furanylmethylamino)-1,3-dimethylpurine-2,6-dione | 7-[(2,4-dichlorophenyl)methyl]-8-(furan-2-ylmethylamino)-1,3-dimethyl-purine-2,6-dione | 7-[(2,4-dichlorophenyl)methyl]-8-(furan-2-ylmethylamino)-1,3-dimethylpurine-2,6-dione | MLS000830306 | SMR000035471 | cid_657771
Type:
Small organic molecule
Emp. Form.:
C19H17Cl2N5O3
Mol. Mass.:
434.276
SMILES:
Cn1c2nc(NCc3ccco3)n(Cc3ccc(Cl)cc3Cl)c2c(=O)n(C)c1=O
Structure:
Search PDB for entries with ligand similarity: