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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90147
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90147
Synonyms:
2-[4-Methoxy-3-(pyridin-2-ylsulfanylmethyl)-phenyl]-3-phenyl-2,3-dihydro-1H-quinazolin-4-one | 2-[4-methoxy-3-(pyridin-2-ylsulfanylmethyl)phenyl]-3-phenyl-1,2-dihydroquinazolin-4-one | 2-[4-methoxy-3-[(2-pyridinylthio)methyl]phenyl]-3-phenyl-1,2-dihydroquinazolin-4-one | 2-[4-methoxy-3-[(2-pyridylthio)methyl]phenyl]-3-phenyl-1,2-dihydroquinazolin-4-one | MLS000588924 | SMR000212612 | cid_4326095
Type:
Small organic molecule
Emp. Form.:
C27H23N3O2S
Mol. Mass.:
453.555
SMILES:
COc1ccc(cc1CSc1ccccn1)C1Nc2ccccc2C(=O)N1c1ccccc1
Structure:
Search PDB for entries with ligand similarity: