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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90871
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90871
Synonyms:
3-[(2-fluorobenzoyl)amino]-4-methyl-thiophene-2-carboxylic acid methyl ester | 3-[[(2-fluorophenyl)-oxomethyl]amino]-4-methyl-2-thiophenecarboxylic acid methyl ester | MLS001195457 | SMR000550656 | cid_4558229 | methyl 3-[(2-fluorobenzoyl)amino]-4-methyl-2-thiophenecarboxylate | methyl 3-[(2-fluorobenzoyl)amino]-4-methylthiophene-2-carboxylate | methyl 3-[(2-fluorophenyl)carbonylamino]-4-methyl-thiophene-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C14H12FNO3S
Mol. Mass.:
293.313
SMILES:
COC(=O)c1scc(C)c1NC(=O)c1ccccc1F
Structure:
Search PDB for entries with ligand similarity: