Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM58586
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
5360±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM58586
Synonyms:
2-Fluoro-benzoic acid N'-(4-hydroxy-1-methyl-2-oxo-1,2-dihydro-quinoline-3-carbonyl)-hydrazide | MLS001217552 | N''-(2-fluorobenzoyl)-2-hydroxy-1-methyl-4-oxoquinoline-3-carbohydrazide | N''-(2-fluorobenzoyl)-4-hydroxy-2-keto-1-methyl-quinoline-3-carbohydrazide | N''-(2-fluorophenyl)carbonyl-1-methyl-2-oxidanyl-4-oxidanylidene-quinoline-3-carbohydrazide | N''-[(2-fluorophenyl)-oxomethyl]-2-hydroxy-1-methyl-4-oxo-3-quinolinecarbohydrazide | N'-(2-fluorobenzoyl)-2-hydroxy-4-keto-1-methyl-quinoline-3-carbohydrazide | N'-(2-fluorobenzoyl)-4-hydroxy-2-keto-1-methyl-quinoline-3-carbohydrazide | SMR000608064 | cid_3115944
Type:
Small organic molecule
Emp. Form.:
C18H14FN3O4
Mol. Mass.:
355.3199
SMILES:
Cn1c2ccccc2c(O)c(C(=O)NNC(=O)c2ccccc2F)c1=O
Structure:
Search PDB for entries with ligand similarity: