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Target
ATP-binding cassette sub-family B member 6
Ligand
BDBM47475
Substrate
n/a
Meas. Tech.
Dose Response of Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Cherry Pick01
EC50
210±n/a nM
Citation
 PubChem, PC Dose Response of Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Cherry Pick01 PubChem Bioassay (2012)[AID] 
Target
Name:
ATP-binding cassette sub-family B member 6
Synonyms:
ABCB6 | ABCB6_HUMAN | ATP-binding cassette sub-family B member 6, mitochondrial | MTABC3 | PRP | UMAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
93896.51
Organism:
Homo sapiens (Human)
Description:
gi_9955963
Residue:
842
Sequence:
MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGADSLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGACGLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADLGQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTMER
  
Inhibitor
Name:
BDBM47475
Synonyms:
2-[[(Z)-[2-[3-(diethylsulfamoyl)phenyl]-1,3-bis(oxidanylidene)isoquinolin-4-ylidene]methyl]amino]benzoic acid | 2-[[(Z)-[2-[3-(diethylsulfamoyl)phenyl]-1,3-diketo-4-isoquinolylidene]methyl]amino]benzoic acid | 2-[[(Z)-[2-[3-(diethylsulfamoyl)phenyl]-1,3-dioxo-4-isoquinolinylidene]methyl]amino]benzoic acid | 2-[[(Z)-[2-[3-(diethylsulfamoyl)phenyl]-1,3-dioxoisoquinolin-4-ylidene]methyl]amino]benzoic acid | MLS001002340 | SMR000368858 | cid_6108189
Type:
Small organic molecule
Emp. Form.:
C27H25N3O6S
Mol. Mass.:
519.569
SMILES:
CCN(CC)S(=O)(=O)c1cccc(c1)-n1c(O)c(C=Nc2ccccc2C(O)=O)c2ccccc2c1=O |w:19.20|
Structure:
Search PDB for entries with ligand similarity: