Reaction Details Report a problem with these data
Target
Kallikrein-5 [D153N]
Ligand
BDBM113283
Substrate
n/a
Meas. Tech.
KLK5 Assay
pH
8±n/a
Temperature
310.15±n/a K
Ki
1000±n/a nM
Comments
extracted
Citation
 Wagberg, F; Leonardsson, G Benzoxazinone derivatives for treatment of skin diseases US Patent  US9695194 Publication Date 7/4/2017 
Target
Name:
Kallikrein-5 [D153N]
Synonyms:
KLK-L2 | KLK5 | KLK5_HUMAN | Kallikrein 5 | Kallikrein-5 | Kallikrein-like protein 2 | SCTE | Stratum corneum tryptic enzyme
Type:
PROTEIN
Mol. Mass.:
32031.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1282456
Residue:
293
Sequence:
MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNNLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS
  
Inhibitor
Name:
BDBM113283
Synonyms:
US9695194, 8
Type:
Small organic molecule
Emp. Form.:
C19H17NO6
Mol. Mass.:
355.3414
SMILES:
COc1ccc(c(OC)c1)-c1nc2cc3OCCCOc3cc2c(=O)o1
Structure:
Search PDB for entries with ligand similarity: