Reaction Details Report a problem with these data
Target
Tryptophanase
Ligand
BDBM91689
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
7.8±0
Temperature
298.15±0 K
Ki
174000000±9000000 nM
Citation
 Scherzer, R; Gdalevsky, GY; Goldgur, Y; Cohen-Luria, R; Bittner, S; Parola, AH New tryptophanase inhibitors: towards prevention of bacterial biofilm formation. J Enzyme Inhib Med Chem 24:350-5 (2009) [PubMed]  Article 
Target
Name:
Tryptophanase
Synonyms:
L-tryptophan indole-lyase | TNAA_ECOLI | ind | tnaA
Type:
Enzyme
Mol. Mass.:
52770.85
Organism:
Escherichia coli
Description:
P0A853
Residue:
471
Sequence:
MENFKHLPEPFRIRVIEPVKRTTRAYREEAIIKSGMNPFLLDSEDVFIDLLTDSGTGAVTQSMQAAMMRGDEAYSGSRSYYALAESVKNIFGYQYTIPTHQGRGAEQIYIPVLIKKREQEKGLDRSKMVAFSNYFFDTTQGHSQINGCTVRNVYIKEAFDTGVRYDFKGNFDLEGLERGIEEVGPNNVPYIVATITSNSAGGQPVSLANLKAMYSIAKKYDIPVVMDSARFAENAYFIKQREAEYKDWTIEQITRETYKYADMLAMSAKKDAMVPMGGLLCMKDDSFFDVYTECRTLCVVQEGFPTYGGLEGGAMERLAVGLYDGMNLDWLAYRIAQVQYLVDGLEEIGVVCQQAGGHAAFVDAGKLLPHIPADQFPAQALACELYKVAGIRAVEIGSFLLGRDPKTGKQLPCPAELLRLTIPRATYTQTHMDFIIEAFKHVKENAANIKGLTFTYEPKVLRHFTAKLKEV
  
Inhibitor
Name:
BDBM91689
Synonyms:
Alpha-amino-2-(9,10-anthraquinone)-popanoic acid
Type:
Small organic molecule
Emp. Form.:
C17H13NO4
Mol. Mass.:
295.2894
SMILES:
NC(Cc1ccc2C(=O)c3ccccc3C(=O)c2c1)C(O)=O
Structure:
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