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Target
Phosphodiesterase
Ligand
BDBM23620
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.5±0
Temperature
297.15±0 K
IC50
6.9e+3± 4.0e+3 nM
Citation
 Wang, H; Kunz, S; Chen, G; Seebeck, T; Wan, Y; Robinson, H; Martinelli, S; Ke, H Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors. J Biol Chem 287:11788-97 (2012) [PubMed]  Article 
Target
Name:
Phosphodiesterase
Synonyms:
Cyclic nucleotide specific phosphodiesterase | Phosphodiesterase (TcrPDEC)
Type:
Protein
Mol. Mass.:
103074.59
Organism:
Trypanosoma cruzi
Description:
Q53I59
Residue:
924
Sequence:
MSEDAGLPVPRSQWVERGVSCATCGKRFSLFTAKSNCPCCGKLCCSDCVQAECAIVGGSAPSKVCIDCFSMLQSRRRVEPDEGSSFREFNAASAFPLQTRLLADGRVESGETSRVSPPNDGRVQHVSRANGYSNSLPVLDEYVDDLLRKSELLRMENDVLLNRLREQEAEIHALRLERDRAVARIVPDGGSMAGRSGLPQVSDEIVKELRGELAVAHLRIESVKRELKNALDRAKSSETMVRNLKQGLCNYKEEVVRPLQSREEVEMLPGVNGRRDMISTRRLPPSIVQDTILAVVPPKSCAAIGTDVDLRDWGFDTFEVASRVPSVLQSVAMHVALAWNFFASQEEAQKWAFLVAAVENNYRPNPYHNAIHAADVLQGTFSLVSAAKPLMEHLTPLECKAAAFAALTHDVCHPGRTNAFLAAVQDPVSFKFSGKGTLEQLHTVTAFELLNVTEFDFTSSMDNASFLEFKNIVSHLIGHTDMSLHSETIAKHGAKLSAGGFDCTCKEDRLEALSLLLHAADIGASSRGVAIARKWLVILQEFADQAEDERRRGLPVTPGFDTPSSVEKSQIPFLDFFVIPTFDLLHQLFPSIEEPLHNLRKLRELYAAKAGVTTPFPPPVDYRSREERIRSLEAELAYFRRREEEFHRQLQELRTASENENKSSAAPMTREGALNKQSQLVCRGEGNMNADWADAGGGFRNGKDVRDLQDVSMDHLVSSKTVESDTGDSGPRGRRGSKAETTKAYERKLGEREAALMATARLLENREKRLAVFSEKLAEIAEGLHEERKRLQPMEEFKTPCFSRETELISEESASMDVTHRFSTQWEAEERLARKYRELDELLLIVRAMRMGYAARRNTNLGWKALSATLAEREAAISEAVELSRQRRRHLEEGRGPHPTATHLDRLENATFQLMSAITLLTQC
  
Inhibitor
Name:
BDBM23620
Synonyms:
2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)pyrimido[5,4-d][1,3]diazin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol | CHEMBL932 | Dipyridamine | Dipyridamole | Dipyudamine | MLS000028420 | Persantine | SMR000058382 | cid_3108
Type:
Small organic molecule
Emp. Form.:
C24H40N8O4
Mol. Mass.:
504.6256
SMILES:
OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO
Structure:
Search PDB for entries with ligand similarity: