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Target
Putative glycogen synthase kinase 3 alpha
Ligand
BDBM13530
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>5.0e+4±n/a nM
Citation
 Grütter, C; Simard, JR; Mayer-Wrangowski, SC; Schreier, PH; Pérez-Martí­n, J; Richters, A; Getlik, M; Gutbrod, O; Braun, CA; Beck, ME; Rauh, D Targeting GSK3 from Ustilago maydis: Type-II Kinase Inhibitors as Potential Antifungals. ACS Chem Biol 7:1257-67 (2012) [PubMed]  Article 
Target
Name:
Putative glycogen synthase kinase 3 alpha
Synonyms:
Glycogen Synthase Kinase 3 (GSK3)
Type:
Protein
Mol. Mass.:
45420.65
Organism:
Ustilago maydis (Smut fungus)
Description:
A0A0D1CGS9
Residue:
402
Sequence:
MSNAPLNGVKLNPLDDPNKVIKVLASDGKTGEQREIAYTNCKVIGNGSFGVVFQAKLVSQGSEPAEGSSKESDEVAIKKVLQDKRFKNRELQIMRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDELRTGEARMPNGRELPPLFNWTKEELSVRPDLISRLVPQHAEAELLSRGIDVHNFQPIPLESLKVTLD
  
Inhibitor
Name:
BDBM13530
Synonyms:
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide | CHEMBL941 | Gleevec | Imatinib | Imatinib, 21 | N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide | STI-571 | STI571 | US10906896, Cpd imatinib | US11649218, Example Imatinib | US11725005, Compound imatinib | US9255107, Imatinib | cid_5291 | imatinib-CD3 | med.21724, Compound 6
Type:
Small organic molecule
Emp. Form.:
C29H31N7O
Mol. Mass.:
493.6027
SMILES:
CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Structure:
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