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Target
Phosphoethanolamine N-methyltransferase 1
Ligand
BDBM28422
Substrate
n/a
Meas. Tech.
Calorimetric (ITC) Assay
pH
7.5000±0.0000
Temperature
293.1500±0.0000 K
Kd
1.66e+4± 1.7e+3 nM
Citation
 Lee, SG; Haakenson, W; McCarter, JP; Williams, DJ; Hresko, MC; Jez, JM Thermodynamic evaluation of ligand binding in the plant-like phosphoethanolamine methyltransferases of the parasitic nematode Haemonchus contortus. J Biol Chem 286:38060-8 (2011) [PubMed]  Article 
Target
Name:
Phosphoethanolamine N-methyltransferase 1
Synonyms:
Phosphoehtnaolamine Methyltransferases 1 (PMT1)
Type:
Enzyme
Mol. Mass.:
53531.36
Organism:
Caenorhabditis elegans
Description:
Q86NB3
Residue:
475
Sequence:
MSTDQQSSVEDQTVAMVNVRRANFKSFWDKYSDKPDTNSMMLNHSAEELESSDRADILASLPLLHNKDVVDIGAGIGRFTTVLAETARWVLSTDFIDSFIKKNQERNAHLGNINYQVGDAVGLKMESNSVDLVFTNWLMMYLSDEETVEFIFNCMRWLRSHGIVHLRESCSEPSTGRSKAKSMHDTANANPTHYRFSSLYINLLRAIRYRDVDNKLWRFNVQWSCSVPTYIKRSNNWRQVHWLAEKVPAEDGAKGTSFNELVELIKNTWQNEQEAWDAKLDDEKYVWTDKVFSSALTSLPSNSTFFLYTPRTVSPYCHINAHTLAETFNANVWNTEIIPEYYRTSLTKSNNLKDQRVRFGWNQSLTDSVTYWQQKDALFDVFVATEFLSTVDDETIRQLPNVMSDGAKFITLEPVDEVNEAEMKQRIQELGYTLKSFTDVTDQCIEAQEQYFKDHEQLRDEKVIRKNWVLLELTH
  
Inhibitor
Name:
BDBM28422
Synonyms:
(2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(methyl)sulfanylium)butanoate | [14COOH]AdoMet | AdoMet | S-Adenosylmethionine | S-adenosyl-L-[carboxy-14C]methionine
Type:
radiolabeled substrate
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: