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Target
Matrix metalloproteinase-25
Ligand
BDBM92488
Substrate
n/a
Meas. Tech.
Inhibition Assay
Temperature
310.15±0 K
IC50
9e+2±n/a nM
Citation
 Radichev, IA; Remacle, AG; Shiryaev, SA; Purves, AN; Johnson, SL; Pellecchia, M; Strongin, AY Biochemical characterization of the cellular glycosylphosphatidylinositol-linked membrane type-6 matrix metalloproteinase. J Biol Chem 285:16076-86 (2010) [PubMed]  Article 
Target
Name:
Matrix metalloproteinase-25
Synonyms:
Leukolysin | MMP-25 | MMP20 | MMP25 | MMP25_HUMAN | MMPL1 | MT-MMP 6 | MT6-MMP | MT6MMP | MTMMP6 | Matrix metalloproteinase-25 | Membrane-type matrix metalloproteinase 6 | Membrane-type-6 matrix metalloproteinase | Membrane-type-6 matrix metalloproteinase (MT6-MMP)
Type:
Protein
Mol. Mass.:
62564.84
Organism:
Homo sapiens (Human)
Description:
Q9NPA2
Residue:
562
Sequence:
MRLRLRLLALLLLLLAPPARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGGARPLTELGLPPGEEVDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSSGPRAPRPPKATPVSETCDCQCELNQAAGRWPAPIPLLLLPLLVGGVASR
  
Inhibitor
Name:
BDBM92488
Synonyms:
BI-92G11
Type:
Small organic molecule
Emp. Form.:
C9H11NO4S
Mol. Mass.:
229.253
SMILES:
ONC(=O)CCS(=O)(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: