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Target
Cytochrome P450 144
Ligand
BDBM24656
Substrate
n/a
Meas. Tech.
Binding Assay
Kd
2.80e+5± 1.8e+4 nM
Citation
 Driscoll, MD; McLean, KJ; Levy, C; Mast, N; Pikuleva, IA; Lafite, P; Rigby, SE; Leys, D; Munro, AW Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen. J Biol Chem 285:38270-82 (2010) [PubMed]  Article 
Target
Name:
Cytochrome P450 144
Synonyms:
CP144_MYCTO | Cytochrome P450 144 (CYP144) | cyp144
Type:
Enzyme
Mol. Mass.:
47207.78
Organism:
Mycobacterium tuberculosis
Description:
P9WPL0
Residue:
434
Sequence:
MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDPYPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVALMELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGGWLPSILVRRIERLELAVQ
  
Inhibitor
Name:
BDBM24656
Synonyms:
4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole | 4-phenylimidazole, 4-PI | CHEMBL14145 | US9138393, 4-Phenyl- imidazole | US9144538, 4-Phenylimidazole
Type:
Small organic molecule
Emp. Form.:
C9H8N2
Mol. Mass.:
144.1732
SMILES:
c1nc(c[nH]1)-c1ccccc1
Structure:
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