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Target
Glutamine-dependent NAD(+) synthetase
Ligand
BDBM92597
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8.5±0
Temperature
310.15±0 K
IC50
2.48e+4± 1.5e+3 nM
Citation
 Boshoff, HI; Xu, X; Tahlan, K; Dowd, CS; Pethe, K; Camacho, LR; Park, TH; Yun, CS; Schnappinger, D; Ehrt, S; Williams, KJ; Barry, CE Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli. J Biol Chem 283:19329-41 (2008) [PubMed]  Article 
Target
Name:
Glutamine-dependent NAD(+) synthetase
Synonyms:
NAD synthetase | NADE_HUMAN | NADSYN1
Type:
Enzyme
Mol. Mass.:
79282.89
Organism:
Homo sapiens (Human)
Description:
Q6IA69
Residue:
706
Sequence:
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWTPHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPRVKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGVDSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTPQDPRDLCGRILTTCYMASKNSSQETCTRARELAQQIGSHHISLNIDPAVKAVMGIFSLVTGKSPLFAAHGGSSRENLALQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIGGISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSVYGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTTLTPAYHAENYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAEPQSLDGVD
  
Inhibitor
Name:
BDBM92597
Synonyms:
CHEMBL324501 | NAD Synthetase Inhibitor, 2
Type:
Organic molecule
Emp. Form.:
C34H43N2O3
Mol. Mass.:
527.7163
SMILES:
C[N+](C)(C)c1ccc(CC(=O)OCCCCCCCCn2ccc3cc(OCc4ccccc4)ccc23)cc1
Structure:
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