Reaction Details Report a problem with these data
Target
Glutamine-dependent NAD(+) synthetase
Ligand
BDBM92600
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8.5±0
Temperature
310.15±0 K
IC50
5.78e+4± 2.2e+3 nM
Citation
Boshoff, HI; Xu, X; Tahlan, K; Dowd, CS; Pethe, K; Camacho, LR; Park, TH; Yun, CS; Schnappinger, D; Ehrt, S; Williams, KJ; Barry, CE Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli. J Biol Chem 283:19329-41 (2008) [PubMed] Article
More Info.:
Target
Name:
Glutamine-dependent NAD(+) synthetase
Synonyms:
NAD synthetase | NADE_HUMAN | NADSYN1
Type:
Enzyme
Mol. Mass.:
79282.89
Organism:
Human
Description:
Q6IA69
Residue:
706
Sequence:
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWTPHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPRVKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGVDSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTPQDPRDLCGRILTTCYMASKNSSQETCTRARELAQQIGSHHISLNIDPAVKAVMGIFSLVTGKSPLFAAHGGSSRENLALQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIGGISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSVYGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTTLTPAYHAENYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAEPQSLDGVD