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Target
cAMP-dependent protein kinase type I-alpha regulatory subunit
Ligand
BDBM92674
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7.4±0
Temperature
303.15±0 K
IC50
5.50e+5±n/a nM
Citation
 Chijiwa, T; Hagiwara, M; Hidaka, H A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testis. J Biol Chem 264:4924-7 (1989) [PubMed] 
Target
Name:
cAMP-dependent protein kinase type I-alpha regulatory subunit
Synonyms:
KAP0_BOVIN | PRKAR1A | cAMP-dependent protein kinase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42885.14
Organism:
Bos taurus
Description:
gi_115496662
Residue:
380
Sequence:
MASGTTASEEERSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFEKLEKEEAKQIQNLQKAGSRADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV
  
Inhibitor
Name:
BDBM92674
Synonyms:
Isoquinolinesulfonamide, CKI-7
Type:
Small molecule
Emp. Form.:
C11H12ClN3O2S
Mol. Mass.:
285.75
SMILES:
NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12
Structure:
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