Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM92677
Substrate
n/a
Meas. Tech.
Phospholipase A2 Vesicle Assay
pH
9±0
Temperature
313.15±0 K
IC50
2.6e+4±n/a nM
Citation
 Lister, MD; Glaser, KB; Ulevitch, RJ; Dennis, EA Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide. J Biol Chem 264:8520-8 (1989) [PubMed] 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM92677
Synonyms:
Manoalogue
Type:
Small molecule
Emp. Form.:
C19H26O4
Mol. Mass.:
318.4073
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]\[#6](-[#6]=O)=[#6]/[#6]-[#6]-[#6]-1=[#6]-[#6](=O)-[#8]-[#6]-1-[#8] |t:16|
Structure:
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