Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM7876
Substrate
n/a
Meas. Tech.
Phospholipase A2 Vesicle Assay
pH
9±0
Temperature
313.15±0 K
IC50
5.50e+5±n/a nM
Citation
 Lister, MD; Glaser, KB; Ulevitch, RJ; Dennis, EA Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide. J Biol Chem 264:8520-8 (1989) [PubMed] 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM7876
Synonyms:
2-bromo-1-(4-bromophenyl)ethan-1-one | Halomethyl Phenyl Ketone deriv. 24 | p-bromophenacyl bromide
Type:
Small organic molecule
Emp. Form.:
C8H6Br2O
Mol. Mass.:
277.941
SMILES:
BrCC(=O)c1ccc(Br)cc1
Structure:
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