Reaction Details Report a problem with these data
Target
Beta-adrenergic receptor kinase 1
Ligand
BDBM46041
Substrate
n/a
Meas. Tech.
Inhibition Assay
Kd
900000±0.0 nM
Citation
 Strader, CD; Candelore, MR; Hill, WS; Sigal, IS; Dixon, RA Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor. J Biol Chem 264:13572-8 (1989) [PubMed] 
Target
Name:
Beta-adrenergic receptor kinase 1
Synonyms:
ADRBK1 | ARBK1_HUMAN | BARK | BARK1 | Beta-ARK-1 | Beta-adrenergic receptor kinase 1 | G-protein coupled receptor kinase 2 | G-protein coupled receptor kinase 2 (GRK2) | GRK2
Type:
Enzyme
Mol. Mass.:
79581.30
Organism:
Homo sapiens (Human)
Description:
P25098
Residue:
689
Sequence:
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLVQRGSANGL
  
Inhibitor
Name:
BDBM46041
Synonyms:
1-(3,4-dihydroxyphenyl)-2-(isopropylamino)ethanone;hydrochloride | 1-(3,4-dihydroxyphenyl)-2-(propan-2-ylamino)ethanone;hydrochloride | 1-(3,4-dihydroxyphenyl)-2-[(propan-2-yl)amino]ethan-1-one, 3 | 1-[3,4-bis(oxidanyl)phenyl]-2-(propan-2-ylamino)ethanone;hydrochloride | CHEMBL598662 | MLS-0315678.0001 | cid_2830496
Type:
Small organic molecule
Emp. Form.:
C11H15NO3
Mol. Mass.:
209.2417
SMILES:
CC(C)NCC(=O)c1ccc(O)c(O)c1
Structure:
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