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Target
Isochorismatase domain-containing protein
Ligand
BDBM92850
Substrate
n/a
Meas. Tech.
GDH-Coupled Nicotinamidase Assay
Ki
140±20 nM
Citation
 French, JB; Cen, Y; Vrablik, TL; Xu, P; Allen, E; Hanna-Rose, W; Sauve, AA Characterization of nicotinamidases: steady state kinetic parameters, classwide inhibition by nicotinaldehydes, and catalytic mechanism. Biochemistry 49:10421-39 (2010) [PubMed]  Article 
Target
Name:
Isochorismatase domain-containing protein
Synonyms:
Nicotinamidase (CePNC1) | Nicotine deamidase
Type:
Enzyme
Mol. Mass.:
37789.90
Organism:
Caenorhabditis elegans
Description:
Q9N426
Residue:
335
Sequence:
MFPCPKLIFPRLMAFIGLIWMVHSDNSATTNNNTILGNQSLEAIPEQLSELTGITVEESERIMESWLGNRQLDLRTSVLFDQEVLSRLRSLRVALLVVDFQNDFVDGSLKIGDGDAGQEPSSAITPLNELLQLSSWDLVVYTKDWHPHNHISFLSQAHNSDRVMDEKDENKTLGFFDSVQFLKPIKTEQVLYPDHCIQKSWGSDIHPEIYIADNAEYIMKGVDPYLDSYSAFNDNNGRSKTELEDLLRRENIDAVVIAGLAYDICVRFTCLDAVKQNFLAAVIPECSAGLTKKGIEESEMAFKKQGVAMISKDEARGITEGGFLPREWVQRIVKK
  
Inhibitor
Name:
BDBM92850
Synonyms:
Nicotinamidase Inhibitor, 17
Type:
Small molecule
Emp. Form.:
C6H4BrNO
Mol. Mass.:
186.006
SMILES:
Brc1cncc(C=O)c1
Structure:
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