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Target
Peptidyl-prolyl cis-trans isomerase B
Ligand
BDBM92915
Substrate
n/a
Meas. Tech.
PPIase Assay
pH
7.8±n/a
Temperature
278.15±n/a K
Ki
2.1e+3± 3e+2 nM
Comments
extracted
Citation
 Daum, S; Schumann, M; Mathea, S; Aumüller, T; Balsley, MA; Constant, SL; de Lacroix, BF; Kruska, F; Braun, M; Schiene-Fischer, C Isoform-specific inhibition of cyclophilins. Biochemistry 48:6268-77 (2009) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase B
Synonyms:
CYP-S1 | CYPB | Cyclophilin B | Cyclophilin B (CypB) | PPIB | PPIB_HUMAN | PPIase | Peptidyl-prolyl cis-trans isomerase B | Rotamase | S-cyclophilin | SCYLP
Type:
Protein
Mol. Mass.:
23751.82
Organism:
Homo sapiens (Human)
Description:
P23284
Residue:
216
Sequence:
MLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE
  
Inhibitor
Name:
BDBM92915
Synonyms:
Aryl 1-indanylketone, 4
Type:
Small molecule
Emp. Form.:
C24H19F3O3
Mol. Mass.:
412.4011
SMILES:
COc1ccc(cc1C(=O)C1CCc2ccccc12)-c1ccc(OC(F)(F)F)cc1
Structure:
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