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Target
Sentrin-specific protease 8
Ligand
BDBM93579
Substrate
n/a
IC50
1210±91 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM93579
Synonyms:
(1S,2S,3S,10bR)-3-benzoyl-2-(4-fluorobenzoyl)spiro[3,10b-dihydro-2H-pyrrol[2,1-a]isoquinoline-1,3'-indoline]-2'-one | (2'S,3S,3'S,10'bR)-2'-(4-fluorophenyl)carbonyl-3'-(phenylcarbonyl)spiro[1H-indole-3,1'-3,10b-dihydro-2H-pyrrolo[2,1-a]isoquinoline]-2-one | (2'S,3S,3'S,10'bR)-3'-benzoyl-2'-(4-fluorobenzoyl)spiro[1H-indole-3,1'-3,10b-dihydro-2H-pyrrolo[2,1-a]isoquinoline]-2-one | (2'S,3S,3'S,10'bR)-3'-benzoyl-2'-[(4-fluorophenyl)-oxomethyl]-2-spiro[1H-indole-3,1'-3,10b-dihydro-2H-pyrrolo[2,1-a]isoquinoline]one | MLS000590115 | SMR000219322 | cid_15944915
Type:
Small organic molecule
Emp. Form.:
C33H23FN2O3
Mol. Mass.:
514.5457
SMILES:
Fc1ccc(cc1)C(=O)[C@@H]1[C@H](N2C=Cc3ccccc3[C@@H]2[C@]11C(=O)Nc2ccccc12)C(=O)c1ccccc1 |c:13|
Structure:
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