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Target
Sentrin-specific protease 8
Ligand
BDBM93580
Substrate
n/a
IC50
577±50 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM93580
Synonyms:
5-amino-N'-(4-chlorobenzylidene)-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carbohydrazide | 5-amino-N-[(E)-(4-chlorobenzylidene)amino]-4-keto-3-phenyl-thieno[3,4-d]pyridazine-1-carboxamide | 5-amino-N-[(E)-(4-chlorophenyl)methylideneamino]-4-oxo-3-phenyl-1-thieno[3,4-d]pyridazinecarboxamide | 5-amino-N-[(E)-(4-chlorophenyl)methylideneamino]-4-oxo-3-phenylthieno[3,4-d]pyridazine-1-carboxamide | 5-azanyl-N-[(E)-(4-chlorophenyl)methylideneamino]-4-oxidanylidene-3-phenyl-thieno[3,4-d]pyridazine-1-carboxamide | MLS000544578 | SMR000164095 | cid_49849259
Type:
Small organic molecule
Emp. Form.:
C20H14ClN5O2S
Mol. Mass.:
423.875
SMILES:
Nc1scc2c(nn(-c3ccccc3)c(=O)c12)C(=O)N\N=C\c1ccc(Cl)cc1
Structure:
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