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Target
Sentrin-specific protease 8
Ligand
BDBM70989
Substrate
n/a
IC50
2980±340 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM70989
Synonyms:
(7-morpholinobenzofurazan-4-yl)amine | 4-(4-morpholinyl)-2,1,3-benzoxadiazol-7-amine | 4-morpholin-4-yl-2,1,3-benzoxadiazol-7-amine | MLS000764893 | SMR000290498 | cid_1095027
Type:
Small organic molecule
Emp. Form.:
C10H12N4O2
Mol. Mass.:
220.2279
SMILES:
Nc1ccc(N2CCOCC2)c2nonc12
Structure:
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