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Target
Sentrin-specific protease 8
Ligand
BDBM93603
Substrate
n/a
IC50
2310±236 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM93603
Synonyms:
MLS003355872 | N-cyclohexyl-2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-quinolinyl)acetamide | N-cyclohexyl-2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-quinolyl)acetamide | N-cyclohexyl-2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-quinolin-4-yl-ethanamide | N-cyclohexyl-2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-quinolin-4-ylacetamide | SMR002044437 | cid_51361425
Type:
Small organic molecule
Emp. Form.:
C26H29N3O
Mol. Mass.:
399.528
SMILES:
O=C(NC1CCCCC1)C(N1CCc2ccccc2C1)c1ccnc2ccccc12
Structure:
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