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Target
Sentrin-specific protease 8
Ligand
BDBM42140
Substrate
n/a
IC50
2980±299 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM42140
Synonyms:
5,6,7,8-tetrahydro-1,2,4-benzotriazin-3-amine | 5,6,7,8-tetrahydro-1,2,4-benzotriazin-3-ylamine | MLS000040395 | SMR000043358 | cid_591407
Type:
Small organic molecule
Emp. Form.:
C7H10N4
Mol. Mass.:
150.1811
SMILES:
Nc1nnc2CCCCc2n1
Structure:
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