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Target
Sentrin-specific protease 8
Ligand
BDBM93635
Substrate
n/a
IC50
1350±206 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM93635
Synonyms:
MLS001004252 | N-[(E)-[(3E)-3-(isonicotinoylhydrazono)indan-1-ylidene]amino]isonicotinamide | N-[(E)-[(3E)-3-(pyridin-4-ylcarbonylhydrazinylidene)inden-1-ylidene]amino]pyridine-4-carboxamide | N-[(E)-[(3E)-3-(pyridine-4-carbonylhydrazinylidene)inden-1-ylidene]amino]pyridine-4-carboxamide | N-[(E)-[(3E)-3-[[oxo(pyridin-4-yl)methyl]hydrazinylidene]-1-indenylidene]amino]-4-pyridinecarboxamide | SMR000347809 | cid_9701594
Type:
Small organic molecule
Emp. Form.:
C21H16N6O2
Mol. Mass.:
384.3907
SMILES:
O=C(N\N=C1/C\C(=N/NC(=O)c2ccncc2)c2ccccc12)c1ccncc1
Structure:
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