Reaction Details Report a problem with these data
Target
Sentrin-specific protease 8
Ligand
BDBM83932
Substrate
n/a
IC50
1640±137 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM83932
Synonyms:
5-bromanyl-1-methyl-quinolin-1-ium-8-olate;hydrate | 5-bromo-1-methyl-8-quinolin-1-iumolate;hydrate | 5-bromo-1-methyl-quinolin-1-ium-8-olate;hydrate | 5-bromo-1-methylquinolin-1-ium-8-olate;hydrate | MLS000767218 | SMR000429549 | cid_16682477
Type:
Small organic molecule
Emp. Form.:
C10H8BrNO
Mol. Mass.:
238.081
SMILES:
C[n+]1cccc2c(Br)ccc([O-])c12
Structure:
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