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Target
Sentrin-specific protease 8
Ligand
BDBM42151
Substrate
n/a
IC50
2680±298 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM42151
Synonyms:
(5aR,9aS)-10-oxidanidyl-5-oxidanylidene-5a,6,7,8,9,9a-hexahydroindeno[1,2-b]quinoxalin-5-ium-11-one | (5aR,9aS)-10-oxido-5-oxo-5a,6,7,8,9,9a-hexahydroindeno[1,2-b]quinoxalin-5-ium-11-one | (5aR,9aS)-5-keto-10-oxido-5a,6,7,8,9,9a-hexahydroindeno[1,2-b]quinoxalin-5-ium-11-one | (5aR,9aS)-5a,6,7,8,9,9a-hexahydro-11H-indeno[1,2-b]quinoxalin-11-one 5,10-dioxide | MLS000089701 | SMR000024319 | cid_1886595
Type:
Small organic molecule
Emp. Form.:
C15H14N2O3
Mol. Mass.:
270.2833
SMILES:
[O-]N1[C@H]2CCCC[C@H]2[N+](=O)C2=C1C(=O)c1ccccc21 |c:11|
Structure:
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