Reaction Details Report a problem with these data
Target
Sentrin-specific protease 8
Ligand
BDBM80085
Substrate
n/a
IC50
1740±227 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM80085
Synonyms:
10-(diiodomethylene)phenanthren-9-one | 10-(diiodomethylidene)-9-phenanthrenone | 10-(diiodomethylidene)phenanthren-9-one | 10-[bis(iodanyl)methylidene]phenanthren-9-one | MLS002702485 | SMR001566046 | cid_400634
Type:
Small organic molecule
Emp. Form.:
C15H8I2O
Mol. Mass.:
458.0324
SMILES:
I\[#6](I)=[#6]-1/[#6](=O)-c2ccccc2-c2ccccc-12
Structure:
Search PDB for entries with ligand similarity: