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Target
Sentrin-specific protease 8
Ligand
BDBM83993
Substrate
n/a
IC50
2680±285 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM83993
Synonyms:
6-(2-morpholin-4-ylethylamino)quinolin-8-ol;2,2,2-trifluoroacetic acid | 6-(2-morpholin-4-ylethylamino)quinolin-8-ol;2,2,2-tris(fluoranyl)ethanoic acid | 6-(2-morpholinoethylamino)quinolin-8-ol;2,2,2-trifluoroacetic acid | 6-[2-(4-morpholinyl)ethylamino]-8-quinolinol;2,2,2-trifluoroacetic acid | MLS002391564 | SMR001355532 | cid_44143222
Type:
Small organic molecule
Emp. Form.:
C15H19N3O2
Mol. Mass.:
273.3303
SMILES:
Oc1cc(NCCN2CCOCC2)cc2cccnc12
Structure:
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