Reaction Details Report a problem with these data
Target
Caspase-3
Ligand
BDBM93586
Substrate
n/a
IC50
45500±1690 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 in a Caspase-3 Fluorescence assay PubChem Bioassay (2012)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM93586
Synonyms:
6-(2-ethoxyethoxy)-N-(phenylmethyl)-1-propan-2-yl-4-benzimidazolamine | 6-(2-ethoxyethoxy)-N-(phenylmethyl)-1-propan-2-yl-benzimidazol-4-amine | MLS002471404 | N-benzyl-6-(2-ethoxyethoxy)-1-propan-2-ylbenzimidazol-4-amine | SMR001395070 | benzyl-[6-(2-ethoxyethoxy)-1-isopropyl-benzimidazol-4-yl]amine | cid_44143050
Type:
Small organic molecule
Emp. Form.:
C21H27N3O2
Mol. Mass.:
353.458
SMILES:
CCOCCOc1cc(NCc2ccccc2)c2ncn(C(C)C)c2c1
Structure:
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