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Target
Caspase-3
Ligand
BDBM93685
Substrate
n/a
IC50
>100000±0 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 in a Caspase-3 Fluorescence assay PubChem Bioassay (2012)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM93685
Synonyms:
5-nitro-2-furancarboxylic acid [2-oxo-2-[2-(4-sulfamoylphenyl)ethylamino]ethyl] ester | 5-nitrofuran-2-carboxylic acid [2-keto-2-[2-(4-sulfamoylphenyl)ethylamino]ethyl] ester | MLS002245421 | SMR001309073 | [2-oxidanylidene-2-[2-(4-sulfamoylphenyl)ethylamino]ethyl] 5-nitrofuran-2-carboxylate | [2-oxo-2-[2-(4-sulfamoylphenyl)ethylamino]ethyl] 5-nitrofuran-2-carboxylate | cid_2083726
Type:
Small organic molecule
Emp. Form.:
C15H15N3O8S
Mol. Mass.:
397.36
SMILES:
NS(=O)(=O)c1ccc(CCNC(=O)COC(=O)c2ccc(o2)[N+]([O-])=O)cc1
Structure:
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