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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM72600
Substrate
n/a
IC50
3770±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM72600
Synonyms:
2-(methylthio)-3-pyridinecarboxylic acid [2-(4-methoxyphenyl)-2-oxoethyl] ester | 2-(methylthio)nicotinic acid [2-keto-2-(4-methoxyphenyl)ethyl] ester | MLS001004314 | SMR000347835 | [2-(4-methoxyphenyl)-2-oxidanylidene-ethyl] 2-methylsulfanylpyridine-3-carboxylate | [2-(4-methoxyphenyl)-2-oxoethyl] 2-methylsulfanylpyridine-3-carboxylate | cid_2358127
Type:
Small organic molecule
Emp. Form.:
C16H15NO4S
Mol. Mass.:
317.36
SMILES:
COc1ccc(cc1)C(=O)COC(=O)c1cccnc1SC
Structure:
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